Ritika Gautam Singh's Lab
Publications
Ayushi Chaudhary, Himanshu Sonker, Kajal Chaudhary, Ashwini Kumar, Nidhi Awasthi, Bhumika Agrahari, Ritika Gautam Singh* Ir(III) Nanoaggregates as Photodynamic Antimicrobial Agents against Resistant S. aureus in a Wound Healing Mouse Model. ACS Infectious Diseases, Accepted on 12th January 2026.
Click the link here: https://doi.org/10.1021/acsinfecdis.5c00562
Bharat Singh, Suraj Kashyap, Gaurav Goswami, Ashwini Kumar, Prabodh Ranjan, Preeti Chahar, Swapnanil Sen, Ranajit Mal, Ritika Gautam Singh*, Manas K. Ghorai*, Synthesis of azepino[4,5-b]indoles and benzo[f][1,5]diazecine-2,8(1H,3H)diones: promising anti-cancer activity toward cervical and brain cancer. Organic Chemistry Frontiers, Accepted on 13th November 2025.
Click the link here: https://doi.org/10.1039/D5QO01306B
Archana Yadav, Sayari Dewan, Kajal Chaudhary, Ray J. Butcher, Ritika Gautam Singh, and Raja Angamuthu*. Hemiparetic Koneramine NNP Ligand Comprising Strategic Hard and Soft Donors: Transition Metal Complexes, CS2 Activation and
Therapeutic Potential, Dalton Transaction, Dalton Transaction, Accepted on 7th November 2025.
Click the link here: https://doi.org/10.1039/D5DT02106E
Kajal Chaudhary, Bhumika Agrahari, Himanshu Sonker, Sayari Dewan, Ritika Gautam Singh*. Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii Journal of Medicinal Chemistry, 17th October 2025.
Click the link here: https://doi.org/10.1021/acs.jmedchem.5c00790
Himanshu Sonker, Sayari Dewan, Kajal Chaudhary, Bhumika Agrahari, Neelam Rathore, Pranshu Jain, Ritika Gautam Singh*. Water-Soluble Ruthenium(II) p-Cymene Complexes Mitigating Intracellular S. aureus Infection: Bridging Antibacterial Défense and Anticancer Therapy Journal of Medicinal Chemistry, 2025, 68, 16, 17897–17916.
Click the link here: https://doi.org/10.1039/D5MD00290G
Sayari Dewan, Himanshu Sonker, Kajal Chaudhary and Ritika Gautam Singh*. Rational Design of Gold(I)-NHC Complexes as Anticancer Agents: Induction of Necroptosis and Paraptosis in Lung Adenocarcinoma RSC Medicinal Chemistry, 2025,16, 4208-4219
Click the link here: https://doi.org/10.1039/D5MD00290G
Ashwini Kumar, Ayushi Chaudhary, Ankit Ankit, Arjun Swamimalai Venkatraman, Sujit Kumar Gond, Sanhita Sinharay and Ritika Gautam Singh*. .Redox-Active Iron Complex as Immunogenic Cell Death Inducer with NIR-II Photoacoustic Properties: Potential Theragnostic Agent for “Cold Tumors” Inorganic Chemistry Frontiers, 2025, 12, 5658-5675
Click the link here: https://doi.org/10.1039/D5QI00575B
Soumyadeep De, Ayushi Chaudhary, Abhishek Yogi, Nikhil Shrivas, Ritika Gautam Singh, Venkata Jayasurya Yallapragada, Vishal Govind Rao*. Dual Functionality of Bidentate Ligands for Optimized Charge Extraction in Lead Halide Perovskites: Implications for Perovskite Solar Cells ACS Applied Nano Materials, 2025, 8, 23, 12164–12175.
Click the link here: https://doi.org/10.1021/acsanm.5c01828
Sayari Dewan, Himanshu Sonker, Kajal Chaudhary, Saloni Agrawal, Ayushi Chaudhary, Ashwini Kumar, Bhumika Agrahari, and Ritika Gautam Singh*. Self-Assembling Imidazolium Nanoaggregates Trigger a Unique Dynamin-Dependent Cell Death via Cytoplasmic Vacuolization and Mitochondrial Dysfunction in Human Lung Adenocarcinoma. Journal of Medicinal Chemistry, 2025, 68, 11, 11801–11819.
Click the link here: https://doi.org/10.1021/acs.jmedchem.5c00651
Sidhanta Nanda, Mohammad Adeel Zafar, Sanpreet Singh, Jonaid Ahmad Malik, Ritika Gautam Singh, Abhishek Ghosh, Debasish Basu, Javed N Agrewala*. Chronic administration of morphine provokes generation of antibodies to morphine and immunosuppression in individuals with opioid use disorder. Journal of Biosciences 2025, 50 (2). (Indian Academy of Sciences)
Click the link here: https://doi.org/10.1007/s12038-025-00504-8
Bhumika Agrahari, Kajal Chaudhary, Sayari Dewan, Himanshu Sonker, Arjun S.V, Anshuman Chandra, Nidhi Awasthi, Hanumanthappa Makari, Sanhita Sinharay, Ritika Gautam Singh*. Theragnostic Dual-Action Platform: Ruthenium p-Cymene-Derived Metalloantibiotics With NIR-II Photoacoustic Spectral Signal. Small, 2025, 26, 2503986
Click the link here: https://doi.org/10.1002/smll.202503986
Ayushi Chaudhary, Ashwini Kumar, Ankit, Ritika Gautam Singh*. Discovery of Cu(II)-Dipyridophenazine Complex for Synergistic Cuproptosis/Chemodynamic Therapy via Disrupting the Tricarboxylic Acid (TCA) Cycle in Metastatic TNBC. Small, 2025. 26, 2504554
Click the link here: https://doi.org/10.1002/smll.202504554.
Himanshu Sonker, Kajal Chaudhary, Bhumika Agrahari, Sayari Dewan, Ankit, Ayushi Chaudhary, Ashwini Kumar, Nikhil Swain, Ritika Gautam Singh*. De Novo 3-(Phenylcarbamoyl) Benzoate Analogues: Efficacy against Multidrug-Resistant S. aureus and Elucidation of the Biodistribution Profile. Journal of Medicinal Chemistry, 2025, 68, 10, 10329–10345.
Click the link here: https://doi.org/10.1021/acs.jmedchem.5c00515.
Ayushi Chaudhary, Ashwini Kumar, Nikhil Swain, Kajal Chaudhary, Himanshu Sonker, Sayari Dewan, Rutwik Anil Patil, Ritika Gautam Singh*. Endocytic Uptake of Self-Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple-Negative Breast Tumor Spheroids. Small, 2025, 13, 2406809
Click the link here: https://doi.org/10.1002/smll.202406809.
Cover Art Selection - Ayushi Chaudhary, Ashwini Kumar, Nikhil Swain, Kajal Chaudhary, Himanshu Sonker, Sayari Dewan, Rutwik Anil Patil, Ritika Gautam Singh*. Endocytic Uptake of Self-Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple-Negative Breast Tumor Spheroids.
Small, 2025, 13, 2406809.
Click the link here: https://doi.org/10.1002/smll.202406809.
Pooja Aggarwal, Ayushi Chaudhary, Siddharth Singh, Ritika Gautam Singh, Vishal Govind Rao*. Leveraging Phenazine-Based Ligands for Optimized Perovskite Optoelectronic Performance Through Chelation and Redox Engineering. Advanced Optical Materials, 2025, 13, 2402047(1-10).
Click the link here: https://doi.org/10.1002/adom.202402047.
Pooja Aggarwal, Ayushi Chaudhary, Soumyadeep De, Ritika Gautam Singh, Vishal Govind Rao*. Long-Lived Charge Separation Enabled by Molecular Engineering of Phenazine-Based Hole Transport Materials. Small, 2025, 2501649 (1 - 9)
Click the link here: https://doi.org/10.1002/smll.202501649
Q&A with Dr Ritika Gautam-Singh.
Communications Chemistry volume 7, Article number: 217 (2024)
Click the link here: https://doi.org/10.1038/s42004-024-01302-3
Kajal Chaudhary, Bhumika Agrahari, Bhumika Biswas, Niranjan Chatterjee, Ayushi Chaudhary, Ashwini Kumar, Himanshu Sonker, Sayari Dewan, Deepanshi Saxena, Abdul Akhir, Nidhi Malhotra, Sidharth Chopra, Santosh Misra, Saravanan Matheswaran, Ritika Gautam Singh*. Pyridine-2,6-Dicarboxamide Proligands and their Cu(II)/Zn(II) Complexes Targeting Staphylococcus Aureus for the Attenuation of In Vivo Dental Biofilm. Advanced Healthcare Materials, 2024, 13, 2400378 (1-21)
Click the link here: https://doi.org/10.1002/adhm.202400378.
Ashwini Kumar, Ayushi Chaudhary, Himanshu Sonker, Seemadri Subhadarshini, Mohit K. Jolly, Ritika Gautam Singh*. Zinc(II) Complexes of SIRTi1/2 Analogues Transmetallating with Copper Ions and Inducing ROS Mediated Paraptosis. ACS Organic & Inorganic Au, 2024, 4, 3, 319–328.
Published as part of ACS Organic & Inorganic Au virtual special issue “2023 Rising Stars in Organic and Inorganic Chemistry”.
Click the link here: https://doi.org/10.1021/acsorginorgau.3c00052.
Franc Meyer, P. Shiv Halasyamani, Géraldine Masson
ACS Organic & Inorganic Au’s 2023 Rising Stars Unveiled
Dr. Ritika was selected among the 2023 Rising Stars in Organic and Inorganic Chemistry by the editors of the American Chemical Society journal ACS Organic & Inorganic Au
Click the link here: https://doi.org/10.1021/acsorginorgau.4c00012
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Ashwini Kumar, Ayushi Chaudhary, Bhumika Agrahari, Kajal Chaudhary, Pooran Kumara, Ritika Gautam Singh*. Concurrent Cu(II)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy. Chemical Communication, 2023, 59, 14305-14308.
Click the link here: https://doi.org/10.1039/D3CC04519F
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Dr. Ritika was selected among the Contributors to the Emerging Investigators collection 2023: Part 2. Chemical Communication., 2023,59, 14738-14744.
Click the link here: https://doi.org/10.1039/D3CC90387G.
Israel Rodríguez,* Ritika Gautam Singh,* Arthur D. Tinoco,* X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization.
Click the link here: https://doi.org/10.3390/biomimetics6010001
Publications between 2019 - 2023
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Kumar, A.; Thompson, B.; Gautam, R; Tomat, E., Huxter, V*. Temperature-Dependent Spin-Driven Dimerization Determines the Ultrafast Dynamics of a Copper(II)-Bound Tripyrrindione Radical, J. Phys. Chem. Lett. 2023, 50, 11268–11273.
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Cho, B; Swain, A.; Gautam, R; Tomat, E., Huxter, V. Time-Resolved Dynamics of Stable Open- and Closed-Shell Neutral Radical and Oxidized Tripyrrindione Complexes. Phys. Chem. Chem. Phys. 2022, 24, 15718-15725. (Featured as a 2022 Editor's Choice HOT Article)
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Swain, A., Cho, B., Gautam, R., Curtis, C., Tomat, E., and Huxter, V. M. Ultrafast Dynamics of Tripyrrindiones in Solution Mediated by Hydrogen-Bonding Interactions. Journal of Physical Chemistry B, 123, 2019, 5524–5535.
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Wenthur. C.J.; Gautam, R.; Zhou, B.; Vendruscolo, L.F.; Leggio, L.; Janda, K. Ghrelin Receptor Infuence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl Ghrelin, Scientific Reports, 2019, 9, 1841-51.
Publications before 2019
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Jacob, N.T., Miranda, P.O, Shirey, R.J., Gautam. R., Zhou, B., Izquierdo, M.E.O., Hixon, M.S., Hart, J.R., Ueno, L., Vogt, P.K., Janda, K.D. Synthetic molecules for disruption of the MYC protein-protein interface. Bioorganic & Medicinal Chemistry, 2018, 26, 4234-4239.
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Gautam, R.; Loughrey, J. J.; Astashkin, A. V.; Shearer, J.; Tomat, E. Tripyrrindione as a redox-active ligand: Palladium (II) coordination in three redox states. Angewandte Chemie, 2015, 127, 15107-15110
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Gautam, R.; Tsuhen M Chang.; Astashkin, A. V.; Lincoln. K. M.; Tomat, E. Propentdyopent: A heme metabolite as an electron reservoir in transition metal complexes. Chemical Communications, 2016, 52, 6585-6588
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Gautam, R.; Akam, E. A.; Astashkin, A. V.; Loughrey, J. J.; Tomat, E. Sirtuin inhibitor sirtinol is an intracellular iron chelator. Chemical Communications, 2015, 51, 5104–5107
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Gautam, R.; Astashkin, A. V.; Chang, T. M.; Shearer, J.; Tomat, E. Interactions of Metal-Based and Ligand-Based Electronic Spins in Neutral Tripyrrindione π-Dimers. Inorganic Chemistry, 2017, 56, 6755–6762.
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Gautam, R.; Petritis, S. J.; Astashkin, A. V.; Shearer, J.; Tomat, E. Zinc binding by redox-active biopyrrin ligands: Paramagnetism and fluorescence of zinc(II) tripyrrindione. 2018, Inorganic Chemistry, 2018.
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Rooker, D. R.; Klyubka, Y.; Gautam. R.; Tomat. E.; Buccella, D. Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation. ChemBioChem, 2018, 19, 496-604.
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Gautam, R.; Petritis, S. J; Tomat, E. Redox-switchable blue fluorescence of a BODIPY analog inspired by propentdyopent pigments. European Journal of Inorganic Chemistry, 2018, 1, 68-72
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Miranda, P; Jacob, N; Shirey, R; Gautam, R; Zhou, B; Izquierdo, M E; Hixon, M; Hart, J; Ueno, L; Vogt, P; Janda, K. Synthetic Molecules for Disruption of the MYC Protein-Protein Interface. Bioorganic & Medicinal Chemistry, 2018, 26, 4234-4239.
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Akam, E. A.; Gautam, R.; Tomat, E., Metal-binding effects of sirtuin inhibitor sirtinol. Supramolecular Chemistry, 2015, 28, 108-116.